PIC Implements Imputation of Selection Candidates
GLOBAL - PIC has announced the continued acceleration of genetic improvement by successfully developing and routinely implementing imputation of 60K SNP genotypes for nucleus selection candidates. This leading-edge technology is driven by the combination of 60K SNP genotypes of parents
with the individual candidate’s genotypes for 300-400 markers. The result is extremely high accuracy for
estimated breeding values for each pig within a litter at a very early age. Previously, 60K genotypes of the
parents were only able to give an average genomic EBV to the litter.
“As an example of this dramatic transformation, genomic selection for total number born based on
parental 60k genotypes improved accuracy by 11 per cent; adding imputed selection candidate 60k genotypes
resulted in a 68 per cent increase in accuracy“ says Dr Selma Forni, Genus Quantitative Research Geneticist.
This significant advancement in swine breeding was made possible through an active research
partnership with the University of New England in Australia. Scientists from the university and Genus
developed the methodology and software necessary to implement imputation into PIC’s industry leading
genomic selection platform.
“This has been a two and half year project that began with funding research with UNE,“ says Dr Matthew
Cleveland, Genus Quantitative Research Scientist.
“A key element to the successful implementation of
the imputation process was PIC’s extensive genomic database of over 20,000 animals genotyped on the
60K chip test - the largest genomic database in the industry - that allowed us to ‘train’ the software. PIC
then developed the proprietary test for the candidates, verified the imputation result, developed the
software system for automated production of breeding values and finally invested in a substantial upgrade
in computing power to routinely handle over one billion genotypes“.
“PIC has is leading the global livestock industry in the practical implementation of genomic imputation into
routine genetic evaluations,“ says Dr. Matt Culbertson, PIC Director of Global Product Development.
“While all the leading pig breeding companies are trying to begin to apply genomic selection, PIC is
leading in the depth and scale of that implementation and the resulting increases in rates of genetic
improvement will bring higher productivity and profitability to our customers.“