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Mechanism Found for AMR Development

1 December 2011, at 11:28pm

US - Antibiotics in pig feed encourage gene exchange between gut bacteria, which may lead to the development of antimicrobial resistance (AMR), according to USDA researchers.

A study published in the online journal, mBio® shows that adding antibiotics to swine feed causes microorganisms in the guts of these animals to start sharing genes that could spread antibiotic resistance, according to Science Daily.

Livestock farms use antibiotic drugs regularly, and not just for curing sick animals. Antimicrobial drugs are used as feed additives to boost animal growth, a profitable but controversial practice that is now banned in the European Union and under scrutiny here in the United States. Using antibiotics in animal feed saves farms money, but opponents argue the practice encourages antimicrobial resistance among bacteria that could well be consumed by humans. Today, livestock producers in the US use an estimated 24.6 million pounds of antimicrobials for non-therapeutic purposes every year. The US Government Accountability Office recently urged the federal government to follow up on plans to evaluate the impacts of the use of antibiotics as growth promoters.

The study by Heather Allen and her colleagues at the USDA National Animal Disease Center (NaDC) in Ames, Iowa, adds to the sum of knowledge about what happens to the microorganisms that populate animal digestive tracts when they are exposed to low, persistent levels of antibiotics. The researchers studied how two in-feed antibiotic formulations affect prophages, segments of DNA found in bacteria that can encode antibiotic resistance genes and other genes that bacteria may use.

Prophages can cut themselves out of the larger chromosome of bacterial DNA in a process called induction, then replicate and package themselves as viruses. These viruses explode the cell from the inside then move on to infect other organisms and deliver their genes.

Dr Allen, who is lead author on the study, says when pigs were fed antibiotics, the actual numbers of antibiotic resistance genes carried by the phages remained steady, but the microorganisms still reacted to the presence of antibiotics. Prophages underwent a significant increase in induction when exposed to antibiotics, indicating that medicating the animals led to increased movement of prophage genes among gut bacteria.

She said: "Induction of the prophages is showing us that antibiotics are stimulating gene transfer. This is significant because phages have previously been shown to carry bacterial fitness genes such as antibiotic resistance genes."

Studies that explore the impacts of in-feed antibiotics most often focus on the bacterial residents of the gut, according to Dr Allen but phages and other viruses move a significant amount of genetic information around the community. This makes changes in prophage induction an important collateral effect of antibiotic treatment, she says. Resistance genes are the unit of currency among microbes experiencing the duress of an antibiotic, so following the movement of genes is arguably more important than following certain changes in bacterial communities. And if bacteria in humans acquire resistance genes from animals, there can be serious health consequences, reports Science Daily.

Dr Allen added: "What's important is the transfer of a gene that could get into the wrong place at the wrong time. Increased gene transfer is a critical event in the evolution of gut bacteria."

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