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    Needle-free jet injectors for intradermal vaccination of pigs: the importance of precision

    The skin is an attractive target for vaccination as it constitutes the major barrier for the entry of environmental pathogens, while at the same time being accessible for vaccine administration.
    calendar icon 17 July 2019
    clock icon 6 minute read
    By: Molina J., Pedrazuela R., Busquet M.
    Europe
    Figure 1. Hipradermic® needle-free jet injector for intradermal application of vaccines.
    Figure 1. Hipradermic® needle-free jet injector for intradermal application of vaccines.
    Figure 2. Impact of a vaccine fluid accelerated by a needle-free jet injector (Hipradermic®) when penetrating acrylamide gel (in vitro model that simulates skin-like stiffness; Taberner et al., 2012).
    Figure 2. Impact of a vaccine fluid accelerated by a needle-free jet injector (Hipradermic®) when penetrating acrylamide gel (in vitro model that simulates skin-like stiffness; Taberner et al., 2012).
    Figure 3. Representation of the three different pressure stages of a needle- free device during the intradermal administration of a vaccine into pig skin.
    Figure 3. Representation of the three different pressure stages of a needle- free device during the intradermal administration of a vaccine into pig skin.
    Figure 4. Intradermal and transdermal distribution of a specific vaccine in pig skin with different needle-free injector devices shown with real-time X-ray. Administration of the vaccine to the back region of the pig (A) and to the neck region of the pig (B). Internal study.
    Figure 4. Intradermal and transdermal distribution of a specific vaccine in pig skin with different needle-free injector devices shown with real-time X-ray. Administration of the vaccine to the back region of the pig (A) and to the neck region of the pig (B). Internal study.
    References
    References
    Chase C.L .,et al
    (2008) . Swine Health Prod 254-260
    Kris E.E, et al.
    (2012) . Vacuna 30(3):523-38
    Martinez-Miro S., et al.
    (2016) . Vet Res. 12: 171
    Taberner A., et al.
    (2012) . Medical Engineering & Physic 34:1228-1235

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    Molina J., Pedrazuela R., Busquet M.

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